Abstract

The goal of the first two studies in this proposal are to characterize the development of glutamatergic and noradrenergic synapses in the visual cortex and explore the modulatory role of cholinergic and noradrenergic input to them. The last study investigates the role of activity on development of these synapses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008055-09
Application #
2391713
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1990-09-01
Project End
2000-03-31
Budget Start
1997-04-01
Budget End
2000-03-31
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Neurology
Type
Schools of Arts and Sciences
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Sarro, Emma C; Kotak, Vibhakar C; Sanes, Dan H et al. (2008) Hearing loss alters the subcellular distribution of presynaptic GAD and postsynaptic GABAA receptors in the auditory cortex. Cereb Cortex 18:2855-67
Shen, Hui; Gong, Qi Hua; Aoki, Chiye et al. (2007) Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty. Nat Neurosci 10:469-77
Chang, Eric H; Savage, Mary J; Flood, Dorothy G et al. (2006) AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice. Proc Natl Acad Sci U S A 103:3410-5
Aoki, C; Miko, I; Oviedo, H et al. (2001) Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortex. Synapse 40:239-57
El-Husseini, A E; Craven, S E; Chetkovich, D M et al. (2000) Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. J Cell Biol 148:159-72
Firestein, B L; Firestein, B L; Brenman, J E et al. (1999) Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting. Neuron 24:659-72
Erisir, A; Aoki, C (1998) A method of combining biocytin tract-tracing with avidin-biotin-peroxidase complex immunocytochemistry for pre-embedding electron microscopic labeling in neonatal tissue. J Neurosci Methods 81:189-97
Venkatesan, C; Song, X Z; Go, C G et al. (1996) Cellular and subcellular distribution of alpha 2A-adrenergic receptors in the visual cortex of neonatal and adult rats. J Comp Neurol 365:79-95