Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008408-02
Application #
3265736
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1989-12-01
Project End
1991-03-31
Budget Start
1990-12-01
Budget End
1991-03-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Schepens Eye Research Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02114
West-Mays, J A; Sadow, P M; Tobin, T W et al. (1997) Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop. Invest Ophthalmol Vis Sci 38:1367-79
Strissel, K J; Rinehart, W B; Fini, M E (1997) Regulation of paracrine cytokine balance controlling collagenase synthesis by corneal cells. Invest Ophthalmol Vis Sci 38:546-52
Strissel, K J; Girard, M T; West-Mays, J A et al. (1997) Role of serum amyloid A as an intermediate in the IL-1 and PMA-stimulated signaling pathways regulating expression of rabbit fibroblast collagenase. Exp Cell Res 237:275-87
Strissel, K J; Tessier, M J; Shams, N B et al. (1997) Frog PNKT-4B cells express specific extracellular matrix-degrading enzymes and cytokines correlated with an invasive phenotype. J Exp Zool 278:201-14
Rada, J A; Fini, M E; Hassell, J R (1996) Regionalized growth patterns of young chicken corneas. Invest Ophthalmol Vis Sci 37:2060-7
Fini, M E; Parks, W C; Rinehart, W B et al. (1996) Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. Am J Pathol 149:1287-302
Strissel, K J; Rinehart, W B; Fini, M E (1995) A corneal epithelial inhibitor of stromal cell collagenase synthesis identified as TGF-beta 2. Invest Ophthalmol Vis Sci 36:151-62
Fini, M E; Girard, M T; Matsubara, M et al. (1995) Unique regulation of the matrix metalloproteinase, gelatinase B. Invest Ophthalmol Vis Sci 36:622-33
West-Mays, J A; Strissel, K J; Sadow, P M et al. (1995) Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop. Proc Natl Acad Sci U S A 92:6768-72
Fini, M E; Strissel, K J; Girard, M T et al. (1994) Interleukin 1 alpha mediates collagenase synthesis stimulated by phorbol 12-myristate 13-acetate. J Biol Chem 269:11291-8

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