This grant is a competing renewal with the long-range goal of understanding how cytokines initiate and perpetuate PVR. This application is based on the hypothesis that HA is an important regulator of cytokine production by RPE, that the cytokines influence monocyte recruitment, which in turn perpetuates the wound healing response. To test the hypothesis, the following aims are proposed: (1) to determine the effect of HA on cytokine production, cell proliferation, and cell migration in cultured human RPE and to determine if the effects are mediated by HA receptors; (2) to determine if subretinal fluid (SRF) from patients with rhegmatogenous retinal detachment (RRD) influences cytokine production by human RPE cells and monocytes and what role HA may play in this; and (3) to determine which specific cytokines are in the SRF of eyes with rhegmatogenous retinal detachment that can influence the migration and survival of human monocytes.
| Yang, Ping; Peairs, James J; Tano, Ryotaro et al. (2007) Caspase-8-mediated apoptosis in human RPE cells. Invest Ophthalmol Vis Sci 48:3341-9 |
| Zhang, Nanfei; Peairs, James J; Yang, Ping et al. (2007) The importance of Bcl-xL in the survival of human RPE cells. Invest Ophthalmol Vis Sci 48:3846-53 |
| Yang, Ping; Peairs, James J; Tano, Ryotaro et al. (2006) Oxidant-mediated Akt activation in human RPE cells. Invest Ophthalmol Vis Sci 47:4598-606 |
| Yang, Ping; Wiser, Jessica L; Peairs, James J et al. (2005) Human RPE expression of cell survival factors. Invest Ophthalmol Vis Sci 46:1755-64 |
| Tseng, Wendy; Cortez, Rafael T; Ramirez, Gema et al. (2004) Prevalence and risk factors for proliferative vitreoretinopathy in eyes with rhegmatogenous retinal detachment but no previous vitreoretinal surgery. Am J Ophthalmol 137:1105-15 |
| Yang, Ping; McKay, Brian S; Allen, Janice B et al. (2004) Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. Invest Ophthalmol Vis Sci 45:2438-46 |
| Yang, Ping; McKay, Brian S; Allen, Janice B et al. (2003) Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells. Invest Ophthalmol Vis Sci 44:1339-47 |
| Jaffe, Glenn J; Brownlow, Robert; Hines, John (2003) Modified external needle drainage procedure for rhegmatogenous retinal detachment. Retina 23:80-5 |
| Park, Carl H; Jaffe, Glenn J; Fekrat, Sharon (2003) Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. Am J Ophthalmol 136:419-25 |
