Abstract

The goal of this project is to isolate and characterize genes that are important to the development and function of the Drosophila visual system and to use them to identify human homologs. Two new directions have emerged. One is to use mutant analysis to understand the roles of glia in the visual system and the other is to explore the nature of the interphotoreceptor space in Drosophila. The applicant will continue to use genetic screens and monoclonal antibodies to initiate these studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY009278-08
Application #
2711057
Study Section
Special Emphasis Panel (ZRG1-VISC (01))
Project Start
1991-08-01
Project End
2001-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125

  Publications

Song, Wei; Ranjan, Ravi; Dawson-Scully, Ken et al. (2002) Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah. Neuron 36:105-19
Friedrich, M; Benzer, S (2000) Divergent decapentaplegic expression patterns in compound eye development and the evolution of insect metamorphosis. J Exp Zool 288:39-55
Bonini, N M; Leiserson, W M; Benzer, S (1998) Multiple roles of the eyes absent gene in Drosophila. Dev Biol 196:42-57
Lin, Y J; Seroude, L; Benzer, S (1998) Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282:943-6
Leiserson, W M; Benzer, S; Bonini, N M (1998) Dual functions of the Drosophila eyes absent gene in the eye and embryo. Mech Dev 73:193-202
Tix, S; Eule, E; Fischbach, K F et al. (1997) Glia in the chiasms and medulla of the Drosophila melanogaster optic lobes. Cell Tissue Res 289:397-409
Rogina, B; Benzer, S; Helfand, S L (1997) Drosophila drop-dead mutations accelerate the time course of age-related markers. Proc Natl Acad Sci U S A 94:6303-6
Davis, C A; Benzer, S (1997) Generation of cDNA expression libraries enriched for in-frame sequences. Proc Natl Acad Sci U S A 94:2128-32
Min, K T; Benzer, S (1997) Spongecake and eggroll: two hereditary diseases in Drosophila resemble patterns of human brain degeneration. Curr Biol 7:885-8
Min, K T; Benzer, S (1997) Wolbachia, normally a symbiont of Drosophila, can be virulent, causing degeneration and early death. Proc Natl Acad Sci U S A 94:10792-6

Showing the most recent 10 out of 22 publications