Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY009498-03
Application #
3266895
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1991-06-01
Project End
1994-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Costante, G; Portolano, S; Nishikawa, T et al. (1994) Recombinant thyroid peroxidase-specific autoantibodies. II. Role of individual heavy and light chains in determining epitope recognition. Endocrinology 135:25-30
Jaume, J C; Costante, G; Portolano, S et al. (1994) Recombinant thyroid peroxidase-specific autoantibodies. I. How diverse is the pool of heavy and light chains in immunoglobulin gene libraries constructed from thyroid tissue-infiltrating plasma cells. Endocrinology 135:16-24
McLachlan, S M; Prummel, M F; Rapoport, B (1994) Cell-mediated or humoral immunity in Graves' ophthalmopathy? Profiles of T-cell cytokines amplified by polymerase chain reaction from orbital tissue. J Clin Endocrinol Metab 78:1070-4
McLachlan, S M; Prummel, M F; Jaume, J C et al. (1994) Immunoglobulin A in Graves' orbital tissue: deoxyribonucleic acid amplification by polymerase chain reaction. J Endocrinol Invest 17:247-52
Prummel, M F; Chazenbalk, G; Jaume, J C et al. (1994) Profile of lambda light chain variable region genes in Graves' orbital tissue. Mol Immunol 31:793-802
Jaume, J C; Portolano, S; Prummel, M F et al. (1994) Molecular cloning and characterization of genes for antibodies generated by orbital tissue-infiltrating B-cells in Graves' ophthalmopathy. J Clin Endocrinol Metab 78:348-52
McLachlan, S M; Rapoport, B (1993) Recombinant thyroid autoantigens: the keys to the pathogenesis of autoimmune thyroid disease. J Intern Med 234:347-59
McLachlan, S M; Prummel, M F; Dallow, R L et al. (1993) Amplification by polymerase chain reaction of immunoglobulin heavy and light chain genes from orbital tissue of patients with Graves' ophthalmopathy. Autoimmunity 16:149-52
Portolano, S; Chazenbalk, G D; Hutchison, J S et al. (1993) Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain ""roulette"". J Immunol 150:880-7
Jaume, J C; Prummel, M F; Wiersinga, W M et al. (1993) Thyrotropin receptor autoantibodies recognizing two different epitopes on the TSH receptor: lack of relationship to patient age, sex, and ophthalmopathy. Thyroid 3:291-5

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