Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY009924-03
Application #
2163644
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1994-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of South Alabama
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Peshenko, Igor V; Olshevskaya, Elena V; Yao, Suxia et al. (2010) Activation of retinal guanylyl cyclase RetGC1 by GCAP1: stoichiometry of binding and effect of new LCA-related mutations. Biochemistry 49:709-17
Sarfare, Shanta; Pittler, Steven J (2007) Focus on molecules: rod photoreceptor cGMP-gated cation channel. Exp Eye Res 85:173-4
Ionita, Marcel A; Pittler, Steven J (2007) Focus on molecules: rod cGMP phosphodiesterase type 6. Exp Eye Res 84:1-2
Pittler, Steven J; Zhang, Youwen; Chen, Shiming et al. (2004) Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity. J Biol Chem 279:19800-7
White, J Brandon; Thompson, W Joseph; Pittler, Steven J (2004) Characterization of 3',5' cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: absence of functional PDE6. Mol Vis 10:738-49
White, J B; Taylor, R E; Pittler, S J (2001) Reproducible high efficiency gene transfer into Y79 retinoblastoma cells using adenofection. J Neurosci Methods 106:1-7
Taylor, R E; Shows, K H; Zhao, Y et al. (2001) A PDE6A promoter fragment directs transcription predominantly in the photoreceptor. Biochem Biophys Res Commun 282:543-7
Ardell, M D; Bedsole, D L; Schoborg, R V et al. (2000) Genomic organization of the human rod photoreceptor cGMP-gated cation channel beta-subunit gene. Gene 245:311-8
Mohamed, M K; Taylor, R E; Feinstein, D S et al. (1998) Structure and upstream region characterization of the human gene encoding rod photoreceptor cGMP phosphodiesterase alpha-subunit. J Mol Neurosci 10:235-50
Perrault, I; Rozet, J M; Calvas, P et al. (1996) Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis. Nat Genet 14:461-4

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