Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010814-02
Application #
2164949
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1995-01-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Nowak, Roberta B; Fischer, Robert S; Zoltoski, Rebecca K et al. (2009) Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens. J Cell Biol 186:915-28
Fischer, R S; Quinlan, R A; Fowler, V M (2003) Tropomodulin binds to filensin intermediate filaments. FEBS Lett 547:228-32
Fischer, Robert S; Fritz-Six, Kimberly L; Fowler, Velia M (2003) Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility. J Cell Biol 161:371-80
Lee, A; Morrow, J S; Fowler, V M (2001) Caspase remodeling of the spectrin membrane skeleton during lens development and aging. J Biol Chem 276:20735-42
Fischer, R S; Lee, A; Fowler, V M (2000) Tropomodulin and tropomyosin mediate lens cell actin cytoskeleton reorganization in vitro. Invest Ophthalmol Vis Sci 41:166-74
Lee, A; Fischer, R S; Fowler, V M (2000) Stabilization and remodeling of the membrane skeleton during lens fiber cell differentiation and maturation. Dev Dyn 217:257-70
Woo, M K; Lee, A; Fischer, R S et al. (2000) The lens membrane skeleton contains structures preferentially enriched in spectrin-actin or tropomodulin-actin complexes. Cell Motil Cytoskeleton 46:257-68
Almenar-Queralt, A; Lee, A; Conley, C A et al. (1999) Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. J Biol Chem 274:28466-75
Littlefield, R; Fowler, V M (1998) Defining actin filament length in striated muscle: rulers and caps or dynamic stability? Annu Rev Cell Dev Biol 14:487-525
Fowler, V M (1997) Capping actin filament growth: tropomodulin in muscle and nonmuscle cells. Soc Gen Physiol Ser 52:79-89

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