Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY010848-01A1
Application #
2165012
Study Section
Special Emphasis Panel (ZRG1-VISB (01))
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Zhang, Houbin; Constantine, Ryan; Vorobiev, Sergey et al. (2011) UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci 14:874-80
Ishiba, Yasutsugu; Higashide, Tomomi; Mori, Naoki et al. (2007) Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. Exp Eye Res 84:473-85
Mori, Naoki; Ishiba, Yasutsugu; Kubota, Shinya et al. (2006) Truncation mutation in HRG4 (UNC119) leads to mitochondrial ANT-1-mediated photoreceptor synaptic and retinal degeneration by apoptosis. Invest Ophthalmol Vis Sci 47:1281-92
Kobayashi, Akira; Kubota, Shinya; Mori, Naoki et al. (2003) Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain. FEBS Lett 534:26-32
Kubota, Shinya; Kobayashi, Akira; Mori, Naoki et al. (2002) Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119). Invest Ophthalmol Vis Sci 43:308-13
Kobayashi, A; Higashide, T; Hamasaki, D et al. (2000) HRG4 (UNC119) mutation found in cone-rod dystrophy causes retinal degeneration in a transgenic model. Invest Ophthalmol Vis Sci 41:3268-77
Higashide, T; Inana, G (1999) Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119. Genomics 57:446-50
Higashide, T; McLaren, M J; Inana, G (1998) Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse. Invest Ophthalmol Vis Sci 39:690-8