Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY011521-01
Application #
2165830
Study Section
Special Emphasis Panel (ZRG1-VISC (01))
Project Start
1996-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California Santa Barbara
Department
Type
Organized Research Units
DUNS #
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106

  Publications

Radeke, Monte J; Peterson, Katie E; Johnson, Lincoln V et al. (2007) Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid. Exp Eye Res 85:366-80
Hageman, Gregory S; Hancox, Lisa S; Taiber, Andrew J et al. (2006) Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. Ann Med 38:592-604
Gehrs, Karen M; Anderson, Don H; Johnson, Lincoln V et al. (2006) Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. Ann Med 38:450-71
Hageman, Gregory S; Anderson, Don H; Johnson, Lincoln V et al. (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A 102:7227-32
Johnson, Patrick T; Brown, Meghan N; Pulliam, Bryce C et al. (2005) Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. Invest Ophthalmol Vis Sci 46:4788-95
Anderson, Don H; Talaga, Kevin C; Rivest, Alexander J et al. (2004) Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp Eye Res 78:243-56
Johnson, Patrick T; Lewis, Geoffrey P; Talaga, Kevin C et al. (2003) Drusen-associated degeneration in the retina. Invest Ophthalmol Vis Sci 44:4481-8
Johnson, Lincoln V; Leitner, William P; Rivest, Alexander J et al. (2002) The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci U S A 99:11830-5
Leu, Sergiu T; Batni, Suchitra; Radeke, Monte J et al. (2002) Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration. Exp Eye Res 74:141-54
Anderson, Don H; Mullins, Robert F; Hageman, Gregory S et al. (2002) A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 134:411-31

Showing the most recent 10 out of 16 publications