Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY011983-05
Application #
6694404
Study Section
Visual Sciences A Study Section (VISA)
Program Officer
Shen, Grace L
Project Start
1999-04-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
5
Fiscal Year
2004
Total Cost
$589,918
Indirect Cost
Name
Schepens Eye Research Institute
Department
Type
DUNS #
073826000
City
Boston
State
MA
Country
United States
Zip Code
02114
Hsu, S-M; Mathew, R; Taylor, A W et al. (2014) Ex-vivo tolerogenic F4/80? antigen-presenting cells (APC) induce efferent CD8? regulatory T cell-dependent suppression of experimental autoimmune uveitis. Clin Exp Immunol 176:37-48
Lucas, Kenyatta; Karamichos, Dimitris; Mathew, Rose et al. (2012) Retinal laser burn-induced neuropathy leads to substance P-dependent loss of ocular immune privilege. J Immunol 189:1237-42
Qiao, Hong; Lucas, Kenyatta; Stein-Streilein, Joan (2009) Retinal laser burn disrupts immune privilege in the eye. Am J Pathol 174:414-22
Watte, C M; Nakamura, T; Lau, C H et al. (2008) Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance. J Leukoc Biol 83:928-35
Sonoda, Koh-Hei; Nakamura, Takahiko; Young, Howard A et al. (2007) NKT cell-derived urokinase-type plasminogen activator promotes peripheral tolerance associated with eye. J Immunol 179:2215-22
Nowak, Michael; Stein-Streilein, Joan (2007) Invariant NKT cells and tolerance. Int Rev Immunol 26:95-119
Sugita, Sunao; Keino, Hiroshi; Futagami, Yuri et al. (2006) B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells. Invest Ophthalmol Vis Sci 47:5376-84
Keino, Hiroshi; Takeuchi, Masaru; Kezuka, Takeshi et al. (2006) Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells. Invest Ophthalmol Vis Sci 47:1047-55
Keino, Hiroshi; Masli, Sharmila; Sasaki, Shuji et al. (2006) CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Invest Ophthalmol Vis Sci 47:1533-42
Zhang-Hoover, Jie; Finn, Patricia; Stein-Streilein, Joan (2005) Modulation of ovalbumin-induced airway inflammation and hyperreactivity by tolerogenic APC. J Immunol 175:7117-24

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