Glaucoma is the second leading cause of blindness worldwide. In the United States, approximately 2.5 million Americans are affected by this potentially blinding eye disease. Optical coherence tomography is the only non-invasive imaging technique allowing high-resolution cross-sectional imaging of the human retina. Since glaucoma causes thinning of the retinal nerve fiber layer prior to initial loss of vision, optical coherence tomograhy (which can measure the nerve fiber layer thickness) could enable early detection of glaucoma prior to any permanent loss of vision. This earlier detection would enable earlier treatment to prevent permanent loss of vision. Since glaucoma also causes progressive nerve fiber layer thinning prior to further loss of vision, optical coherence tomography could enable earlier detection of glaucomatous disease progression prior to further permanent loss of vision, enabling more aggressive preventive treatment. Current clinical techniques only allow diagnosis of glaucomatous loss of vision after up to half of the retinal ganglion cells are permanently lost. The overall goal of this research is A) to develop a video rate Optical Coherence Tomography (OCT) system for 3 dimensional high resolution imaging of the human retina and the retinal nerve fiber layer (RNFL), B) to determine the resolution and reproducibility of in vivo retinal nerve fiber layer thickness determination with video rate OCT in normal and glaucoma subjects, C) to correlate in vivo human OCT images with histology of the same eye.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY014975-01A1
Application #
6780055
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Liberman, Ellen S
Project Start
2004-04-01
Project End
2007-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
1
Fiscal Year
2004
Total Cost
$544,579
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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Wu, Huijuan; de Boer, Johannes F; Chen, Teresa C (2011) Reproducibility of retinal nerve fiber layer thickness measurements using spectral domain optical coherence tomography. J Glaucoma 20:470-6
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