The goal of this project is to directly test the magnocellular theory of dyslexia (MTD) by measuring the function of the magnocellular (M) system in the thalamus. Dyslexia is a reading specific disorder that affects 5% of the population. The MTD is a prominent but controversial theory that proposes that the behavioral deficits in dyslexia are a consequence of the dysfunction of the M system in the brain, which is specialized for the processing of transient information. Because the M system cannot be isolated behaviorally, and because the M stream becomes intermixed with other streams in the cortex, the MTD has never been properly tested. However, the M system remains spatially segregated in the sensory nuclei in the thalamus. Therefore, the MTD will be tested using high-resolution functional magnetic resonance imaging (fMRI) to measure thalamic function in each of three independent aims: 1. Is temporal processing in the lateral geniculate nucleus (LGN) and thalamic reticular nucleus (TRN) normal in dyslexia? 2. Does the M portion of the medial geniculate nucleus (MGN) function normally in dyslexia? 3. Does attention modulate the LGN, MGN and TRN normally in dyslexia? In Aims 1 and 2, measuring the M systems in the MGN and LGN will determine whether M dysfunction, if present, is a general property of the brain in dyslexia, or whether it is confined to a single sensory system. One of the primary functions of the thalamus is to control attention, and Aim 3 will test whether the attentional deficits that have been reported in dyslexia are specific to the M system. Together these experiments provide a comprehensive test of MTD and will serve to resolve its validity. which will have an important impact on the understanding and treatment of dyslexia. This project will use a combination of simple stimuli and experimental designs with experimental and analytical techniques that have been proven in our lab to be able to reliably examine the small and noisy subcortical nuclei, including: high-resolution fMRI; massively averaged high- resolution proton-density weighted images that can resolve the anatomical boundaries of the subcortical nuclei; population receptive field modeling of temporal responses and retinotopic and tonotopic organization; and data-driven filtering and clustering. The results of this project will provide an unprecedented direct test that will ultimately settle the legitimacy of the MTD. This will help guide the allocation of future resources in understanding and treating dyslexia.

Public Health Relevance

This study will directly test the magnocellular theory of dyslexia, a prominent but controversial theory proposing that dyslexia, a prevalent reading-specific disorder affecting 5% of the population, is caused by a malfunction of the magnocelluar system of neurons in the brain. This theory has been difficult to test directly because these neurons are not easily isolated in the cortex, but we will measure them in the subcortex using high-resolution functional magnetic resonance imaging. The results of this study will resolve the validity of the magnocellular theory of dyslexia and will help researchers better understand the disorder and develop new treatment strategies.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY028266-01A1
Application #
9603957
Study Section
Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section (SPC)
Program Officer
Flanders, Martha C
Project Start
2018-09-30
Project End
2023-06-30
Budget Start
2018-09-30
Budget End
2019-06-30
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Delaware
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716