Agency
National Institute of Health (NIH)
Institute
Food and Drug Administration (FDA)
Type
Research Project (R01)
Project #
5R01FD001462-02
Application #
3267697
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1989-07-01
Project End
1992-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Pharmacy
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Takamatsu, Narushi; Welage, Lynda S; Hayashi, Yayoi et al. (2002) Variability in cimetidine absorption and plasma double peaks following oral administration in the fasted state in humans: correlation with antral gastric motility. Eur J Pharm Biopharm 53:37-47
Crison, J R; Weiner, N D; Amidon, G L (1997) Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate. J Pharm Sci 86:384-8
Takamatsu, N; Welage, L S; Idkaidek, N M et al. (1997) Human intestinal permeability of piroxicam, propranolol, phenylalanine, and PEG 400 determined by jejunal perfusion. Pharm Res 14:1127-32
Crison, J R; Shah, V P; Skelly, J P et al. (1996) Drug dissolution into micellar solutions: development of a convective diffusion model and comparison to the film equilibrium model with application to surfactant-facilitated dissolution of carbamazepine. J Pharm Sci 85:1005-11
Polli, J E; Amidon, G L (1995) In vitro characterization of sodium glycocholate binding to cholestyramine resin. J Pharm Sci 84:55-61
Amidon, G L; Lennernas, H; Shah, V P et al. (1995) A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12:413-20
Polli, J E; Amidon, G L (1995) Mathematical model and dimensional analysis of glycocholate binding to cholestyramine resin: implications for in vivo resin performance. J Pharm Sci 84:1446-54
Luner, P E; Amidon, G L (1993) Description and simulation of a multiple mixing tank model to predict the effect of bile sequestrants on bile salt excretion. J Pharm Sci 82:311-8
Luner, P E; Amidon, G L (1992) Equilibrium and kinetic factors influencing bile sequestrant efficacy. Pharm Res 9:670-6
Guo, J H; Robertson, R E; Amidon, G L (1991) Influence of physical aging on mechanical properties of polymer free films: the prediction of long-term aging effects on the water permeability and dissolution rate of polymer film-coated tablets. Pharm Res 8:1500-4

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