Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM013306-39
Application #
6687786
Study Section
Physical Biochemistry Study Section (PB)
Program Officer
Ikeda, Richard A
Project Start
1976-01-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
39
Fiscal Year
2004
Total Cost
$395,451
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802

  Publications

Benkovic, Stephen J; Spiering, Michelle M (2017) Understanding DNA replication by the bacteriophage T4 replisome. J Biol Chem 292:18434-18442
Hedglin, Mark; Aitha, Mahesh; Benkovic, Stephen J (2017) Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA. Biochemistry 56:3415-3421
Hedglin, Mark; Benkovic, Stephen J (2017) Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle. Chem Rev 117:7857-7877
Hedglin, Mark; Benkovic, Stephen J (2017) Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA. Biochemistry 56:1824-1835
Spiering, Michelle M; Hanoian, Philip; Gannavaram, Swathi et al. (2017) RNA primer-primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication. Proc Natl Acad Sci U S A 114:5635-5640
Hedglin, Mark; Pandey, Binod; Benkovic, Stephen J (2016) Characterization of human translesion DNA synthesis across a UV-induced DNA lesion. Elife 5:
Hedglin, Mark; Pandey, Binod; Benkovic, Stephen J (2016) Stability of the human polymerase ? holoenzyme and its implications in lagging strand DNA synthesis. Proc Natl Acad Sci U S A 113:E1777-86
Choi, Jung-Suk; Dasari, Anvesh; Hu, Peter et al. (2016) The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta. Nucleic Acids Res 44:1022-35
Noble, Erin; Spiering, Michelle M; Benkovic, Stephen J (2015) Coordinated DNA Replication by the Bacteriophage T4 Replisome. Viruses 7:3186-200
Zhao, Yanhui; Chen, Danqi; Yue, Hongjun et al. (2014) Dark-field illumination on zero-mode waveguide/microfluidic hybrid chip reveals T4 replisomal protein interactions. Nano Lett 14:1952-60

Showing the most recent 10 out of 36 publications