This project seeks to understand the molecular interactions whereby proteins control the activity of imbedded metal ions, which are known to carry out key biochemical reactions, including electron transfer an oxygen activation. Systems of interest include the iron-sulfur class of proteins, copper proteins, molybdenum proteins, and vanadium proteins. Resonance Raman spectroscopy is used to probe structural details of the active sites in important functional states. Further development of the method to increase its utility is an essential part of the program.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM013498-32
Application #
2684622
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1977-08-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
2001-03-31
Support Year
32
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Princeton University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
002484665
City
Princeton
State
NJ
Country
United States
Zip Code
08544
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