The major objective of this work is the application of digital computers to the derivation of synthetic pathways to complex organic structures. A general problem-solving program, LHASA (Logic and Heuristics Applied to Synthetic Analysis), is being developed which can be used interactively by a chemist with simple graphical input-output of structural formulas. The principles and strategies of organic synthesis are being formalized for use by the program. A variety of strategies including long-range search capabilities are being employed in the program. In addition, the vast range of information on synthetic chemistry is being organized and rationalized to provide a rich and effective knowledge base. The program can be applied to problems involving biologically important substances and is available to other scientists. The LHASA project pioneered the field of computer-assisted synthetic analysis. LHASA has been and continues to be the most sophisticated and powerful computer program for synthetic analysis. Our goal is to increase greatly the capabilities of LHASA so that it becomes a valuable and widely used tool in science.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM018519-21
Application #
3269296
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1976-05-01
Project End
1994-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
21
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138