The toxins from Conus geographus venom have been purified. These fall into four classes; two act on the peripheral neuromuscular system and two act on the central nervous system of vertebrates. The first class has been most well characterized; primary sequences of three homologous toxins of this class have been determined, and a preliminary secondary sequence assignment has been completed. These are all basic peptides of 13-15 amino acids, with two disulfide bonds and blocked carboxyl terminii. In the coming year, we plan to determine which structural determinants of the peptides are important for biological activity. Primary sequence determination of the other classes of toxins will also be carried out where feasible.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM022737-09
Application #
3271281
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1978-04-01
Project End
1987-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Schools of Arts and Sciences
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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