Abstract

The overall program for this year includes the following projects: 1) To identify the bands of the light emitted during dismutation of superoxide radicals in both aqueous solutions and aprotic solvents. 2) Study of rates of reaction of O2-/HO2 with compounds of biological interest (Ascorbic Acid and Catalase). 3) Study of possible complex formation between superoxide dismutases and superoxide radicals. 4) Improvement of superoxide generating techniques.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM023656-09
Application #
3271816
Study Section
Radiation Study Section (RAD)
Project Start
1977-01-01
Project End
1985-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Associated University-Brookhaven National Lab
Department
Type
DUNS #
City
Upton
State
NY
Country
United States
Zip Code
11973

  Publications

Rush, J D; Bielski, B H (1995) The oxidation of amino acids by ferrate(V). A pre-mix pulse radiolysis study. Free Radic Res 22:571-9
Rush, J D; Cyr, J E; Zhao, Z et al. (1995) The oxidation of phenol by ferrate(VI) and ferrate(V). A pulse radiolysis and stopped-flow study. Free Radic Res 22:349-60
Bielski, B H (1992) Reactivity of hypervalent iron with biological compounds. Ann Neurol 32 Suppl:S28-32
Hallewell, R A; Imlay, K C; Lee, P et al. (1991) Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines. Biochem Biophys Res Commun 181:474-80
Cyr, J E; Bielski, B H (1991) The reduction of ferrate(VI) to ferrate(V) by ascorbate. Free Radic Biol Med 11:157-60
Bielski, B H (1985) Fast kinetic studies of dioxygen-derived species and their metal complexes. Philos Trans R Soc Lond B Biol Sci 311:473-82