Our new programs include directions towards the total synthesis of the clinically useful antifungal agents amphotericin B and its aglycon, amphotenolide B. The complete structural elucidation of nystatin, another important antifungal therapeutic agent, and its aglycon, nystatonolide and their total synthesis are also important goals of this research. The synthetic sequences to these targets include a """"""""chiral pool"""""""" approach and an """"""""acyclic steroselection"""""""" approach to the requisite key intermediates, their coupling to a long, open chain precursor followed by an intramolecular ketophosphonate-aldehyde condensation to form the macrolide and elaboration to the final target molecules.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM026879-07
Application #
3274339
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1979-09-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104