The analysis of complex mixtures such as biological fluids by gas chromatography often requires the use of selective detectors to discriminate against interfering species and/or enhance the response to desired compounds. However, with the exception of mass spectrometers, most GC detectors are either difficult or impossible to operate in a wide variety of selective and nonselective modes. Although not designed to provide the range and scope of data provided by mass spectrometers, the ion mobility spectrometer is capable of quantitative and low resolution qualitative detection organic compounds. When compared with commonly employed selective detectors such as the electron capture and nitrogen-phosphorus detectors, the ion mobility spectrometer offers the distinct advantage of tunable selectivity. Because of its versatility and low cost when compared to that of mass spectrometers, the instrument has great potential for routine screening of many drugs in biological samples.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029523-03
Application #
3277176
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1983-03-01
Project End
1986-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Washington State University
Department
Type
Schools of Arts and Sciences
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
Hill Jr, H H; Siems, W F; St Louis, R H et al. (1990) Ion mobility spectrometry. Anal Chem 62:1201A-1209A
Morrissey, M A; Siems, W F; Hill Jr, H H (1990) Ion mobility detection of polydimethylsilicone oligomers following supercritical fluid chromatographic separation. J Chromatogr 505:215-25
Morrissey, M A; Hill Jr, H H (1989) Selective detection of underivatized 2,4-dichlorophenoxyacetic acid in soil by supercritical fluid chromatography with ion mobility detection. J Chromatogr Sci 27:529-33
St Louis, R H; Siems, W F; Hill Jr, H H (1989) Evaluation of direct axial sample introduction for ion mobility detection after capillary gas chromatography. J Chromatogr 479:221-31
Shumate, C B; Hill Jr, H H (1989) Coronaspray nebulization and ionization of liquid samples for ion mobility spectrometry. Anal Chem 61:601-6
Rokushika, S; Hatano, H; Hill Jr, H H (1987) Ion mobility spectrometry after supercritical fluid chromatography. Anal Chem 59:8-12
Shumate, C; St Louis, R H; Hill Jr, H H (1986) Table of reduced mobility values from ambient pressure ion mobility spectrometry. J Chromatogr 373:141-73