The objective of this proposal is to continue our studies on developing practical methods for the synthesis of novel bridged polycyclic compounds and biologically active alkaloids via intramolecular cycloaddition reactions of 1-acyldihydropyridines.
Specific aims are (1) to complete the total synthesis of (plus/minus)-gephyrotoxin by the INOC or IMDA routes (2) to investigate approaches to the asymmetric synthesis of (+)- gephyrotoxin, and (3) to study an approach to the synthesis of the Lycopodium alkaloid, (+)-luciduline.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM030255-04A3
Application #
3277910
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1982-08-01
Project End
1988-12-31
Budget Start
1988-04-01
Budget End
1988-12-31
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Utah State University
Department
Type
Schools of Arts and Sciences
DUNS #
City
Logan
State
UT
Country
United States
Zip Code
84322