The object of this proposal is to develop viable synthetic routes to the antitumor agents, phyllanthoside and shikodonin. Phyllanthoside exhibits in vivo activity against the P-388 lymphocytic leukemia in mice, and exceptional in vitro cytotoxicity against cells derived from the human carcinoma of the nasopharynx. Our synthetic plan will provide the corresponding aglycone, phyllanthocin, as the naturally occurring antipode. Shikodonin, isoated from dried plant material, exhibits in vitro cytotoxicity and in vivo antitumor activity against Ehrlich ascites carconoma inoculated in mice. Our synthesis relies heavily on new strategies and the development of new methodologies to construct the highly functionalized skeleton.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM030350-04
Application #
3278057
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1982-02-01
Project End
1986-01-31
Budget Start
1985-02-01
Budget End
1986-01-31
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Cornell University
Department
Type
Schools of Arts and Sciences
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850