This proposal details a methodological study into the synthesis applications of peroxides. These studies serve two major purposes. First, they would provide new information on the reactivity of peroxides and the stereochemical consequences of their reactions. Second, they would illustrate the design of systems which could fully exploit the usefulness of the reactions of peroxides for the synthesis of biologically important natural products. An important result of this work will be the delineation of means for the preparation of related structural types that would not be directly available from the natural product.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM030738-09
Application #
3278587
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1988-09-01
Project End
1990-04-30
Budget Start
1989-05-01
Budget End
1990-04-30
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
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MacFerrin, K D; Terranova, M P; Schreiber, S L et al. (1990) Overproduction and dissection of proteins by the expression-cassette polymerase chain reaction. Proc Natl Acad Sci U S A 87:1937-41
Bowman, M R; MacFerrin, K D; Schreiber, S L et al. (1990) Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A 87:9052-6