Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM031910-09
Application #
2176363
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1985-04-01
Project End
1997-09-29
Budget Start
1994-09-30
Budget End
1997-09-29
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Lu, P; Alterman, M A; Chaurasia, C S et al. (1997) Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. Arch Biochem Biophys 337:1-7
Bambal, R B; Hanzlik, R P (1996) Effects of steric bulk and conformational rigidity on fatty acid omega hydroxylation by a cytochrome P450 4A1 fusion protein. Arch Biochem Biophys 334:59-66
Bambal, R B; Hanzlik, R P (1996) Active site structure and substrate specificity of cytochrome P450 4A1: steric control of ligand approach perpendicular to heme plane. Biochem Biophys Res Commun 219:445-9
Alterman, M A; Chaurasia, C S; Lu, P et al. (1995) Fatty acid discrimination and omega-hydroxylation by cytochrome P450 4A1 and a cytochrome P4504A1/NADPH-P450 reductase fusion protein. Arch Biochem Biophys 320:289-96
Chaurasia, C S; Alterman, M A; Lu, P et al. (1995) Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. Arch Biochem Biophys 317:161-9
Rizk, P N; Hanzlik, R P (1995) Oxidative and non-oxidative metabolism of 4-iodoanisole by rat liver microsomes. Xenobiotica 25:143-50
Alterman, M A; Chaurasia, C S; Lu, P et al. (1995) Heteroatom substitution shifts regioselectivity of lauric acid metabolism from omega-hydroxylation to (omega-1)-oxidation. Biochem Biophys Res Commun 214:1089-94
Riley, P; Hanzlik, R P (1994) Electron transfer in P450 mechanisms. Microsomal metabolism of cyclopropylbenzene and p-cyclopropylanisole. Xenobiotica 24:1-16
Hall, L R; Hanzlik, R P (1991) N-dealkylation of tertiary amides by cytochrome P-450. Xenobiotica 21:1127-38
Hall, L R; Hanzlik, R P (1990) Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450. J Biol Chem 265:12349-55

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