Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034001-12
Application #
2177253
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1984-07-01
Project End
1997-12-31
Budget Start
1996-04-01
Budget End
1997-12-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Anatomy/Cell Biology
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Crisp, Robert J; Knauer, Mary F; Knauer, Daniel J (2002) Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV. J Biol Chem 277:47285-91
Crisp, R J; Knauer, D J; Knauer, M F (2000) Roles of the heparin and low density lipid receptor-related protein-binding sites of protease nexin 1 (PN1) in urokinase-PN1 complex catabolism. The PN1 heparin-binding site mediates complex retention and degradation but not cell surface binding or intern J Biol Chem 275:19628-37
Knauer, D J; Majumdar, D; Fong, P C et al. (2000) SERPIN regulation of factor XIa. The novel observation that protease nexin 1 in the presence of heparin is a more potent inhibitor of factor XIa than C1 inhibitor. J Biol Chem 275:37340-6
Knauer, M F; Crisp, R J; Kridel, S J et al. (1999) Analysis of a structural determinant in thrombin-protease nexin 1 complexes that mediates clearance by the low density lipoprotein receptor-related protein. J Biol Chem 274:275-81
Mentz, S; de Lacalle, S; Baerga-Ortiz, A et al. (1999) Mechanism of thrombin clearance by human astrocytoma cells. J Neurochem 72:980-7
Kridel, S J; Knauer, D J (1997) Lysine residue 114 in human antithrombin III is required for heparin pentasaccharide-mediated activation. J Biol Chem 272:7656-60
Knauer, M F; Kridel, S J; Hawley, S B et al. (1997) The efficient catabolism of thrombin-protease nexin 1 complexes is a synergistic mechanism that requires both the LDL receptor-related protein and cell surface heparins. J Biol Chem 272:29039-45
Knauer, M F; Hawley, S B; Knauer, D J (1997) Identification of a binding site in protease nexin I (PN1) required for the receptor mediated internalization of PN1-thrombin complexes. J Biol Chem 272:12261-4
Kridel, S J; Chan, W W; Knauer, D J (1996) Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III. J Biol Chem 271:20935-41
Smith, J W; Dey, N; Knauer, D J (1990) Heparin binding domain of antithrombin III: characterization using a synthetic peptide directed polyclonal antibody. Biochemistry 29:8950-7

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