Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036358-09
Application #
2178318
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1986-12-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Physiology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Garcia-Moreno, B; Dwyer, J J; Gittis, A G et al. (1997) Experimental measurement of the effective dielectric in the hydrophobic core of a protein. Biophys Chem 64:211-24
Green, S M; Gittis, A G; Meeker, A K et al. (1995) One-step evolution of a dimer from a monomeric protein. Nat Struct Biol 2:746-51
Loll, P J; Quirk, S; Lattman, E E et al. (1995) X-ray crystal structures of staphylococcal nuclease complexed with the competitive inhibitor cobalt(II) and nucleotide. Biochemistry 34:4316-24
Abeygunawardana, C; Weber, D J; Gittis, A G et al. (1995) Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase. Biochemistry 34:14997-5005
Libson, A M; Gittis, A G; Lattman, E E (1994) Crystal structures of the binary Ca2+ and pdTp complexes and the ternary complex of the Asp21-->Glu mutant of staphylococcal nuclease. Implications for catalysis and ligand binding. Biochemistry 33:8007-16
Keefe, L J; Quirk, S; Gittis, A et al. (1994) Accommodation of insertion mutations on the surface and in the interior of staphylococcal nuclease. Protein Sci 3:391-401
Weber, D J; Serpersu, E H; Gittis, A G et al. (1993) NMR docking of the competitive inhibitor thymidine 3',5'-diphosphate into the X-ray structure of staphylococcal nuclease. Proteins 17:20-35
Keefe, L J; Sondek, J; Shortle, D et al. (1993) The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nuclease. Proc Natl Acad Sci U S A 90:3275-9
Gittis, A G; Stites, W E; Lattman, E E (1993) The phase transition between a compact denatured state and a random coil state in staphylococcal nuclease is first-order. J Mol Biol 232:718-24
Weber, D J; Gittis, A G; Mullen, G P et al. (1992) NMR docking of a substrate into the X-ray structure of staphylococcal nuclease. Proteins 13:275-87

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