Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM038250-08
Application #
2179235
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1991-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Toronto
Department
Type
DUNS #
259999779
City
Toronto
State
ON
Country
Canada
Zip Code
M5 1-S8
Pang, K S; Schwab, A J; Goresky, C A et al. (1994) Transport, binding, and metabolism of sulfate conjugates in the liver. Chem Biol Interact 92:179-207
Xu, X; Schwab, A J; Barker 3rd, F et al. (1994) Salicylamide sulfate cell entry in perfused rat liver: a multiple-indicator dilution study. Hepatology 19:229-44
Pang, K S; Sherman, I A; Schwab, A J et al. (1994) Role of the hepatic artery in the metabolism of phenacetin and acetaminophen: intravital microscopic and multiple-indicator dilution study in perfused rat liver. Hepatology 20:672-83
Chiba, M; Poon, K; Hollands, J et al. (1994) Glycine conjugation activity of benzoic acid and its acinar localization in the perfused rat liver. J Pharmacol Exp Ther 268:409-16
Pang, K S; Barker 3rd, F; Schwab, A J et al. (1994) Demonstration of rapid entry and a cellular binding space for salicylamide in perfused rat liver: a multiple indicator dilution study. J Pharmacol Exp Ther 270:285-95
Ratna, S; Chiba, M; Bandyopadhyay, L et al. (1993) Futile cycling between 4-methylumbelliferone and its conjugates in perfused rat liver. Hepatology 17:838-53
Chiba, M; Pang, K S (1993) Effect of protein binding on 4-methylumbelliferyl sulfate desulfation kinetics in perfused rat liver. J Pharmacol Exp Ther 266:492-9
Goresky, C A; Pang, K S; Schwab, A J et al. (1992) Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver. Hepatology 16:173-90
St-Pierre, M V; Lee, P I; Pang, K S (1992) A comparative investigation of hepatic clearance models: predictions of metabolite formation and elimination. J Pharmacokinet Biopharm 20:105-45
Pang, K S; Xu, X; St-Pierre, M V (1992) Determinants of metabolite disposition. Annu Rev Pharmacol Toxicol 32:623-69

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