We wish to study a number of proteins relevant to the regulation of mitochondrial motility and bioenergetics in living cells. The goal of this proposal includes: 1. Identification of mitochondrial outer membrane proteins that interact with microtubules; 2. Identification of mitochondrial outer membrane proteins that interact with intermediate filaments; 3. Microtubule associated proteins that bind mitochondria; 4. Intermediate filaments associated proteins that bind mitochondria; 5. Novel cellular framework proteins that bind mitochondria; 6. Regulation of mitochondrial morphology in living cells; 7. Regulation of mitochondrial electrochemical gradient in living cells.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM038318-05
Application #
3294669
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1987-04-01
Project End
1992-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
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