Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM039750-08
Application #
2180007
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1988-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Biochemistry
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029
Rachofsky, E L; Laws, W R (2000) Kinetic models and data analysis methods for fluorescence anisotropy decay. Methods Enzymol 321:216-38
Zemsky, J; Rusinova, E; Nemerson, Y et al. (1999) Probing local environments of tryptophan residues in proteins: comparison of 19F nuclear magnetic resonance results with the intrinsic fluorescence of soluble human tissue factor. Proteins 37:709-16
Bishop, S M; Ross, J B; Kohanski, R A (1999) Autophosphorylation dependent destabilization of the insulin receptor kinase domain: tryptophan-1175 reports changes in the catalytic cleft. Biochemistry 38:3079-89
Senear, D F; Ross, J B; Laue, T M (1998) Analysis of protein and DNA-mediated contributions to cooperative assembly of protein-DNA complexes. Methods 16:3-20
Bialik, C N; Wolf, B; Rachofsky, E L et al. (1998) Dynamics of biomolecules: assignment of local motions by fluorescence anisotropy decay. Biophys J 75:2564-73
Ross, J B; Szabo, A G; Hogue, C W (1997) Enhancement of protein spectra with tryptophan analogs: fluorescence spectroscopy of protein-protein and protein-nucleic acid interactions. Methods Enzymol 278:151-90
Huang, Y T; Rusinova, E; Ross, J B et al. (1997) An aromatic stacking interaction between subunits helps mediate DNA sequence specificity: operator site discrimination by phage lambda cI repressor. J Mol Biol 267:403-17
Rusinova, E; Ross, J B; Laue, T M et al. (1997) Linkage between operator binding and dimer to octamer self-assembly of bacteriophage lambda cI repressor. Biochemistry 36:12994-3003
Hermann, A; Laws, W R; Harpel, P C (1997) Oxidation of apolipoprotein(a) inhibits kringle-associated lysine binding: the loss of intrinsic protein fluorescence suggests a role for tryptophan residues in the lysine binding site. Protein Sci 6:2324-35
Driscoll, S L; Hawkins, M E; Balis, F M et al. (1997) Fluorescence properties of a new guanosine analog incorporated into small oligonucleotides. Biophys J 73:3277-86

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