Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM039771-10
Application #
2180022
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1988-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Kudo, M; Aono, M; Lee, Y et al. (2001) Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures. Anesthesiology 94:303-212
Kudo, M; Aono, M; Lee, Y et al. (2001) Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures. Anesthesiology 95:756-65
Mackensen, G B; Nellgard, B; Sarraf-Yazdi, S et al. (2000) Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat. Brain Res 853:15-21
Sheng, H; Kudo, M; Mackensen, G B et al. (2000) Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia. Exp Neurol 163:392-8
Nellgard, B; Mackensen, G B; Massey, G et al. (2000) The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. Anesth Analg 91:145-51
Nellgard, B; Mackensen, G B; Pineda, J et al. (2000) Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology 93:431-6
Mackensen, G B; Nellgard, B; Kudo, M et al. (2000) Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. Anesthesiology 93:1102-6
Sheng, H; Laskowitz, D T; Pearlstein, R D et al. (1999) Characterization of a recovery global cerebral ischemia model in the mouse. J Neurosci Methods 88:103-9
Sarraf-Yazdi, S; Sheng, H; Grocott, H P et al. (1999) Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat. Brain Res 826:172-80
Nellgard, B M; Miura, Y; Burkhard Mackensen, G et al. (1999) Effect of intracerebral norepinephrine depletion on outcome from severe forebrain ischemia in the rat. Brain Res 847:262-9

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