Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM041223-12S1
Application #
6846525
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Chin, Jean
Project Start
1988-12-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
12
Fiscal Year
2004
Total Cost
$22,288
Indirect Cost
Name
Johns Hopkins University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Worman, Howard J; Michaelis, Susan (2018) Permanently Farnesylated Prelamin A, Progeria, and Atherosclerosis. Circulation 138:283-286
Spear, Eric D; Hsu, Erh-Ting; Nie, Laiyin et al. (2018) ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability. Dis Model Mech 11:
Ast, Tslil; Michaelis, Susan; Schuldiner, Maya (2016) The Protease Ste24 Clears Clogged Translocons. Cell 164:103-114
Mehmood, Shahid; Marcoux, Julien; Gault, Joseph et al. (2016) Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. Nat Chem 8:1152-1158
Kane, Megan S; Lindsay, Mark E; Judge, Daniel P et al. (2013) LMNA-associated cardiocutaneous progeria: an inherited autosomal dominant premature aging syndrome with late onset. Am J Med Genet A 161A:1599-611
Michaelis, Susan; Hrycyna, Christine A (2013) Biochemistry. A protease for the ages. Science 339:1529-30
Barrowman, Jemima; Wiley, Patricia A; Hudon-Miller, Sarah E et al. (2012) Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity. Hum Mol Genet 21:4084-93
Michaelis, Susan; Barrowman, Jemima (2012) Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease. Microbiol Mol Biol Rev 76:626-51
Barrowman, Jemima; Hamblet, Corinne; Kane, Megan S et al. (2012) Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24. PLoS One 7:e32120
Barrowman, Jemima; Bhandari, Deepali; Reinisch, Karin et al. (2010) TRAPP complexes in membrane traffic: convergence through a common Rab. Nat Rev Mol Cell Biol 11:759-63

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