Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM042763-04A2
Application #
2181654
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1991-07-01
Project End
1999-11-30
Budget Start
1995-12-12
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Austin
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712
Benfield, Aaron P; Whiddon, Benjamin B; Clements, John H et al. (2007) Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch Biochem Biophys 462:47-53
Benfield, Aaron P; Goodey, Nina M; Phillips, Lauren T et al. (2007) Structural studies examining the substrate specificity profiles of PC-PLC(Bc) protein variants. Arch Biochem Biophys 460:41-7
Antikainen, Nina M; Hergenrother, Paul J; Harris, Micheleen M et al. (2003) Altering substrate specificity of phosphatidylcholine-preferring phospholipase C of Bacillus cereus by random mutagenesis of the headgroup binding site. Biochemistry 42:1603-10
Martin, S F; Follows, B C; Hergenrother, P J et al. (2000) The choline binding site of phospholipase C (Bacillus cereus): insights into substrate specificity. Biochemistry 39:3410-5
Martin, S F; DeBlanc, R L; Hergenrother, P J (2000) Determination of the substrate specificity of the phospholipase D from Streptomyces chromofuscus via an inorganic phosphate quantitation assay. Anal Biochem 278:106-10
Martin, S F; Hergenrother, P J (1999) Catalytic cycle of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus. Solvent viscosity, deuterium isotope effects, and proton inventory studies. Biochemistry 38:4403-8
Martin, S F; Hergenrother, P J (1998) General base catalysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus: the role of Glu4 and Asp55. Biochemistry 37:5755-60
Martin, S F; Spaller, M R; Hergenrother, P J (1996) Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146. Biochemistry 35:12970-7