Development of guidelines for the design of pH-sensitive, swelling- controlled release systems for delivery of drugs, bimolecules and genetically-engineered molecules is investigated. The novel systems are produced from hydrophilic, ionic, glassy polymers which can swell in water or biological fluids. Mechanisms of water-soluble solute diffusion through initially glassy, continuously swelling hydrophilic polymer systems are investigated. Experimental studies are performed with crosslinked copolymers of 2-hydroxyethyl methacrylate with methacrylic acid, N-vinyl- pyrrolidone and various acrylamides using several solutes of low or high molecular weight. The effect of degree of crosslinking and dynamic swelling behavior of the polymer on solute diffusion are studied with a combination of diffusion/dissolution/microtoming/microscopy/stress relaxation experiments. The mesh size is determined experimentally by equilibrium swelling studies. Models are developed for the pH sensitivity of the degree of swelling and the dynamic swelling of these hydrogels.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043337-03
Application #
3302401
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1989-12-01
Project End
1993-05-31
Budget Start
1991-12-01
Budget End
1993-05-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
Schools of Engineering
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
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