Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043776-05
Application #
2182178
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1991-01-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Henthorn, T K; Krejcie, T C; Avram, M J (2008) Early drug distribution: a generally neglected aspect of pharmacokinetics of particular relevance to intravenously administered anesthetic agents. Clin Pharmacol Ther 84:18-22
Krejcie, T C; Avram, M J (1999) What determines anesthetic induction dose? It's the front-end kinetics, doctor! Anesth Analg 89:541-4
Krejcie, T C; Avram, M J; Gentry, W B et al. (1997) A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs. J Pharmacokinet Biopharm 25:169-90
Krejcie, T C; Jacquez, J A; Avram, M J et al. (1996) Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs. J Pharmacokinet Biopharm 24:569-88
Krejcie, T C; Henthorn, T K; Shanks, C A et al. (1994) A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in dogs. J Pharmacol Exp Ther 269:609-16
Gentry, W B; Krejcie, T C; Henthorn, T K et al. (1994) Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model. Anesthesiology 81:316-24;discussion 25A
Henthorn, T K; Krejcie, T C; Shanks, C A et al. (1992) Time-dependent distribution volume and kinetics of the pharmacodynamic effector site. J Pharm Sci 81:1136-8
Henthorn, T K; Avram, M J; Krejcie, T C et al. (1992) Minimal compartmental model of circulatory mixing of indocyanine green. Am J Physiol 262:H903-10