In recent years, a number of biologically active compounds having unusual heterocyclic structures have been isolated from a variety of marine organisms, especially sponges and tunicates. The goal of this proposal is the total synthesis of four of these compounds, all of which are novel marine indole alkaloids. They include the cytotoxic sponge alkaloids discorhabdin C, prianosin A, manzamine C and dragmacidin. All of the above represent structural types which have not yet been synthesized.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM044713-02
Application #
3303967
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1991-05-01
Project End
1995-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Alabama in Tuscaloosa
Department
Type
Schools of Arts and Sciences
DUNS #
City
Tuscaloosa
State
AL
Country
United States
Zip Code
35487