Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM044982-05A1
Application #
2182912
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1991-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rutgers University
Department
Biology
Type
Schools of Pharmacy
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Jan, Yi-Hua; Mishin, Vladimir; Busch, Christine M et al. (2006) Generation of specific antibodies and their use to characterize sex differences in four rat P450 3A enzymes following vehicle and pregnenolone 16alpha-carbonitrile treatment. Arch Biochem Biophys 446:101-10
Howard, Carolyn B; Samuel, Jacqueline; Henderson, Shalonda B et al. (2005) Effects of pristane on cytochrome P450 isozyme expression in rat tissues. Int J Environ Res Public Health 2:138-46
Turan, V K; Sanchez, R I; Li, J J et al. (2004) The effects of steroidal estrogens in ACI rat mammary carcinogenesis: 17beta-estradiol, 2-hydroxyestradiol, 4-hydroxyestradiol, 16alpha-hydroxyestradiol, and 4-hydroxyestrone. J Endocrinol 183:91-9
Parimoo, Bhama; Mishin, Vladimir M; Busch, Christine M et al. (2003) Identification of epitopes on cytochrome P450 3A4/5 recognized by monoclonal antibodies. Arch Biochem Biophys 414:244-54
Gunasekera, Nilhan; Musier-Forsyth, Karin; Arriaga, Edgar (2002) Electrophoretic behavior of individual nuclear species as determined by capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 23:2110-6
Turan, V K; Mishin, V M; Thomas, P E (2001) Clotrimazole is a selective and potent inhibitor of rat cytochrome P450 3A subfamily-related testosterone metabolism. Drug Metab Dispos 29:837-42
Parimoo, B; Thomas, P E (2000) Epitope mapping of rat cytochrome P450 2B1 using glutathione S-transferase-2B1 fusion constructs. Arch Biochem Biophys 380:117-25
Nims, R W; Prough, R A; Jones, C R et al. (1997) In vivo induction and in vitro inhibition of hepatic cytochrome P450 activity by the benzodiazepine anticonvulsants clonazepam and diazepam. Drug Metab Dispos 25:750-6
Zhang, X J; Thomas, P E (1996) Erythromycin as a specific substrate for cytochrome P4503A isozymes and identification of a high-affinity erythromycin N-demethylase in adult female rats. Drug Metab Dispos 24:23-7
Ghosal, A; Sadrieh, N; Reik, L et al. (1996) Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin. Arch Biochem Biophys 332:153-62

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