Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM045434-06
Application #
2183167
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1991-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Physiology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Gauthier, T W; Davenpeck, K L; Lefer, A M (1994) Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion. Am J Physiol 267:G562-8
Lefer, A M; Murohara, T; Buerke, M (1994) Effects of taprostene on neutrophil-endothelial interactions in isolated coronary arteries. Methods Find Exp Clin Pharmacol 16:623-31
Buerke, M; Weyrich, A S; Murohara, T et al. (1994) Humanized monoclonal antibody DREG-200 directed against I-selectin protects in feline myocardial reperfusion injury. J Pharmacol Exp Ther 271:134-42
Weyrich, A S; Ma, X L; Buerke, M et al. (1994) Physiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle. Circ Res 75:692-700
Davenpeck, K L; Gauthier, T W; Lefer, A M (1994) Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterology 107:1050-8
Buerke, M; Weyrich, A S; Lefer, A M (1994) Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. Am J Physiol 266:H128-36
Skurk, C; Buerke, M; Guo, J P et al. (1994) Sialyl Lewisx-containing oligosaccharide exerts beneficial effects in murine traumatic shock. Am J Physiol 267:H2124-31
Davenpeck, K L; Gauthier, T W; Albertine, K H et al. (1994) Role of P-selectin in microvascular leukocyte-endothelial interaction in splanchnic ischemia-reperfusion. Am J Physiol 267:H622-30
Lefer, A M; Weyrich, A S; Buerke, M (1994) Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury. Cardiovasc Res 28:289-94
Albertine, K H; Weyrich, A S; Ma, X L et al. (1994) Quantification of neutrophil migration following myocardial ischemia and reperfusion in cats and dogs. J Leukoc Biol 55:557-66

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