. In this proposal, the investigators seek support to: 1) synthesize the potent anti-viral agents avarol and avarone in racemic form, along with the closely related compounds arenarol and arenarone, using a beta-keto phosphonate already prepared as a key intermediate: 2) explore new methodology that should allow preparation of this key intermediate in optically active form; and 3) use optically active b-keto phosphonates to prepare the natural, biologically active enantiomer of avarol. The investigator believes that it is important to follow these leads because of different modes of anti-HIV action of these compounds as compared to nucleoside analogs.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM046631-03
Application #
2184133
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1991-09-30
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1995-08-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Iowa
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242