Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM047502-05
Application #
2184968
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1992-05-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Elkiweri, Iman A; Zhang, Yan Ling; Christians, Uwe et al. (2009) Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats. Anesth Analg 108:149-59
Henthorn, T K; Krejcie, T C; Avram, M J (2008) Early drug distribution: a generally neglected aspect of pharmacokinetics of particular relevance to intravenously administered anesthetic agents. Clin Pharmacol Ther 84:18-22
Avram, Michael J; Krejcie, Tom C; Henthorn, Thomas K et al. (2004) Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution. J Pharmacol Exp Ther 311:617-24
Christians, Uwe (2004) Transport proteins and intestinal metabolism: P-glycoprotein and cytochrome P4503A. Ther Drug Monit 26:104-6
Minto, Charles F; Schnider, Thomas W; Gregg, Keith M et al. (2003) Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics. Anesthesiology 99:324-33
Avram, Michael J; Krejcie, Tom C; Henthorn, Thomas K (2002) The concordance of early antipyrine and thiopental distribution kinetics. J Pharmacol Exp Ther 302:594-600
Avram, M J; Krejcie, T C; Niemann, C U et al. (2000) Isoflurane alters the recirculatory pharmacokinetics of physiologic markers. Anesthesiology 92:1757-68
Cho, C W; Liu, Y; Yan, X et al. (2000) Carrier-mediated uptake of rhodamine 123: implications on its use for MDR research. Biochem Biophys Res Commun 279:124-30
Niemann, C U; Henthorn, T K; Krejcie, T C et al. (2000) Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol. Clin Pharmacol Ther 67:342-50
Waters, C M; Avram, M J; Krejcie, T C et al. (1999) Uptake of fentanyl in pulmonary endothelium. J Pharmacol Exp Ther 288:157-63

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