Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM048712-05
Application #
2186233
Study Section
Special Emphasis Panel (ZRG4-ALTX-4)
Project Start
1992-09-30
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Minoda, Y; Kharasch, E D (2001) Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6). Anesthesiology 95:509-14
Kharasch, E D; Hankins, D C; Fenstamaker, K et al. (2000) Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. Eur J Clin Pharmacol 55:853-9
Kharasch, E D; Jubert, C; Spracklin, D K et al. (1999) Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats. Toxicol Appl Pharmacol 160:49-59
Kharasch, E D; Jubert, C (1999) Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison. Anesthesiology 91:1267-78
Kharasch, E D; Hankins, D C; Cox, K (1999) Clinical isoflurane metabolism by cytochrome P450 2E1. Anesthesiology 90:766-71
Kharasch, E D; Hankins, D C; Jubert, C et al. (1999) Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1. Drug Metab Dispos 27:717-23
Kharasch, E D; Hoffman, G M; Thorning, D et al. (1998) Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats. Anesthesiology 88:1624-33
Spracklin, D K; Kharasch, E D (1998) Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms. Drug Metab Dispos 26:605-7
Kharasch, E D; Frink Jr, E J; Zager, R et al. (1997) Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. Anesthesiology 86:1238-53
Kharasch, E D; Thorning, D; Garton, K et al. (1997) Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats. Anesthesiology 86:160-71

Showing the most recent 10 out of 26 publications