Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM048897-03
Application #
2186414
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1993-08-01
Project End
1997-07-31
Budget Start
1995-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Lu, W; Randal, M; Kossiakoff, A et al. (1999) Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes. Chem Biol 6:419-27
Lu, W; Starovasnik, M A; Kent, S B (1998) Total chemical synthesis of bovine pancreatic trypsin inhibitor by native chemical ligation. FEBS Lett 429:31-5
Muir, T W; Dawson, P E; Kent, S B (1997) Protein synthesis by chemical ligation of unprotected peptides in aqueous solution. Methods Enzymol 289:266-98
Lu, W; Qasim, M A; Laskowski Jr, M et al. (1997) Probing intermolecular main chain hydrogen bonding in serine proteinase-protein inhibitor complexes: chemical synthesis of backbone-engineered turkey ovomucoid third domain. Biochemistry 36:673-9
Muir, T W; Dawson, P E; Fitzgerald, M C et al. (1996) Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis. Chem Biol 3:817-25
Dawson, P E; Muir, T W; Clark-Lewis, I et al. (1994) Synthesis of proteins by native chemical ligation. Science 266:776-9
Baca, M; Kent, S B (1993) Catalytic contribution of flap-substrate hydrogen bonds in ""HIV-1 protease"" explored by chemical synthesis. Proc Natl Acad Sci U S A 90:11638-42