Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049502-12
Application #
2187062
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Boutaud, O; Brash, A R (1999) Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla. J Biol Chem 274:33764-70
Hada, T; Swift, L L; Brash, A R (1997) Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. Biochim Biophys Acta 1346:109-19
Brash, A R; Boeglin, W E; Chang, M S (1997) Discovery of a second 15S-lipoxygenase in humans. Proc Natl Acad Sci U S A 94:6148-52
Jisaka, M; Kim, R B; Boeglin, W E et al. (1997) Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin. J Biol Chem 272:24410-6
Koljak, R; Boutaud, O; Shieh, B H et al. (1997) Identification of a naturally occurring peroxidase-lipoxygenase fusion protein. Science 277:1994-6
Brash, A R; Song, W (1996) Detection, assay, and isolation of allene oxide synthase. Methods Enzymol 272:250-9
Chang, M S; Boeglin, W E; Guengerich, F P et al. (1996) Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products. Biochemistry 35:464-71
Funk, C D; Keeney, D S; Oliw, E H et al. (1996) Functional expression and cellular localization of a mouse epidermal lipoxygenase. J Biol Chem 271:23338-44
Brash, A R; Boeglin, W E; Chang, M S et al. (1996) Purification and molecular cloning of an 8R-lipoxygenase from the coral Plexaura homomalla reveal the related primary structures of R- and S-lipoxygenases. J Biol Chem 271:20949-57
Brash, A R; Song, W C (1995) Structure-function features of flaxseed allene oxide synthase. J Lipid Mediat Cell Signal 12:275-82

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