Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049710-03
Application #
2187245
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1993-09-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Brigham Young University
Department
Zoology
Type
Schools of Earth Sciences/Natur
DUNS #
City
Provo
State
UT
Country
United States
Zip Code
84602
Wilson, H A; Waldrip, J B; Nielson, K H et al. (1999) Mechanisms by which elevated intracellular calcium induces S49 cell membranes to become susceptible to the action of secretory phospholipase A2. J Biol Chem 274:11494-504
Henshaw, J B; Olsen, C A; Farnbach, A R et al. (1998) Definition of the specific roles of lysolecithin and palmitic acid in altering the susceptibility of dipalmitoylphosphatidylcholine bilayers to phospholipase A2. Biochemistry 37:10709-21
Huang, W; Vernon, L P; Hansen, L D et al. (1997) Interactions of thionin from Pyrularia pubera with dipalmitoylphosphatidylglycerol large unilamellar vesicles. Biochemistry 36:2860-6
Wilson, H A; Huang, W; Waldrip, J B et al. (1997) Mechanisms by which thionin induces susceptibility of S49 cell membranes to extracellular phospholipase A2. Biochim Biophys Acta 1349:142-56
Bell, J D; Burnside, M; Owen, J A et al. (1996) Relationships between bilayer structure and phospholipase A2 activity: interactions among temperature, diacylglycerol, lysolecithin, palmitic acid, and dipalmitoylphosphatidylcholine. Biochemistry 35:4945-55
Bell, J D; Baker, M L; Bent, E D et al. (1995) Effects of temperature and glycerides on the enhancement of Agkistrodon piscivorus piscivorus phospholipase A2 activity by lysolecithin and palmitic acid. Biochemistry 34:11551-60
Bent, E D; Bell, J D (1995) Quantification of the interactions among fatty acid, lysophosphatidylcholine, calcium, dimyristoylphosphatidylcholine vesicles, and phospholipase A2. Biochim Biophys Acta 1254:349-60
Sheffield, M J; Baker, B L; Li, D et al. (1995) Enhancement of Agkistrodon piscivorus piscivorus venom phospholipase A2 activity toward phosphatidylcholine vesicles by lysolecithin and palmitic acid: studies with fluorescent probes of membrane structure. Biochemistry 34:7796-806
Huang, W; Vernon, L P; Bell, J D (1994) Enhancement of adenylate cyclase activity in S49 lymphoma cell membranes by the toxin thionin from Pyrularia pubera. Toxicon 32:789-97