Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049760-04
Application #
2187294
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1993-08-01
Project End
1998-03-31
Budget Start
1996-08-01
Budget End
1998-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Tischer, Alexander; Machha, Venkata R; Rösgen, Jörg et al. (2018) ""Cooperative collapse"" of the denatured state revealed through Clausius-Clapeyron analysis of protein denaturation phase diagrams. Biopolymers 109:e23106
Rösgen, Jörg (2015) Synergy in protein-osmolyte mixtures. J Phys Chem B 119:150-7
Dutta, Amit K; Rösgen, Jörg; Rajarathnam, Krishna (2015) Using isothermal titration calorimetry to determine thermodynamic parameters of protein-glycosaminoglycan interactions. Methods Mol Biol 1229:315-24
Rajarathnam, Krishna; Rösgen, Jörg (2014) Isothermal titration calorimetry of membrane proteins - progress and challenges. Biochim Biophys Acta 1838:69-77
Jackson-Atogi, Ruby; Sinha, Prem Kumar; Rosgen, Jorg (2013) Distinctive solvation patterns make renal osmolytes diverse. Biophys J 105:2166-74
Rosgen, Jorg; Jackson-Atogi, Ruby (2012) Volume exclusion and H-bonding dominate the thermodynamics and solvation of trimethylamine-N-oxide in aqueous urea. J Am Chem Soc 134:3590-7
Kokubo, Hironori; Hu, Char Y; Pettitt, B Montgomery (2011) Peptide conformational preferences in osmolyte solutions: transfer free energies of decaalanine. J Am Chem Soc 133:1849-58
Holthauzen, Luis Marcelo F; Auton, Matthew; Sinev, Mikhail et al. (2011) Protein stability in the presence of cosolutes. Methods Enzymol 492:61-125
Auton, Matthew; Rosgen, Jorg; Sinev, Mikhail et al. (2011) Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains. Biophys Chem 159:90-9
Holthauzen, Luis Marcelo F; Rosgen, Jorg; Bolen, D Wayne (2010) Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes. Biochemistry 49:1310-8

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