Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049819-04
Application #
2187364
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1993-08-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Markham, P N; LoGuidice, J; Neyfakh, A A (1997) Broad ligand specificity of the transcriptional regulator of the Bacillus subtilis multidrug transporter Bmr. Biochem Biophys Res Commun 239:269-72
Neyfakh, A A (1997) Natural functions of bacterial multidrug transporters. Trends Microbiol 5:309-13
Markham, P N; Neyfakh, A A (1996) Inhibition of the multidrug transporter NorA prevents emergence of norfloxacin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 40:2673-4
Markham, P N; Ahmed, M; Neyfakh, A A (1996) The drug-binding activity of the multidrug-responding transcriptional regulator BmrR resides in its C-terminal domain. J Bacteriol 178:1473-5
Ahmed, M; Lyass, L; Markham, P N et al. (1995) Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. J Bacteriol 177:3904-10
Ahmed, M; Borsch, C M; Taylor, S S et al. (1994) A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. J Biol Chem 269:28506-13