Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050113-03
Application #
2187720
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1994-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Pharmacy
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Bursavich, Matthew G; Rich, Daniel H (2002) Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles. J Med Chem 45:541-58
Rich, Daniel H; Bursavich, Matthew G; Estiarte, M Angels (2002) Discovery of nonpeptide, peptidomimetic peptidase inhibitors that target alternate enzyme active site conformations. Biopolymers 66:115-25
Travins, J M; Bursavich, M G; Veber, D F et al. (2001) Aspartic protease inhibitors: expedient synthesis of 2-substituted statines. Org Lett 3:2725-8
Bursavich, M G; Rich, D H (2001) Solid-phase synthesis of aspartic peptidase inhibitors: 3-alkoxy-4-aryl piperidines. Org Lett 3:2625-8
West, C W; Estiarte, M A; Rich, D H (2001) New methods for side-chain protection of cysteine. Org Lett 3:1205-8
Ripka, A S; Satyshur, K A; Bohacek, R S et al. (2001) Aspartic protease inhibitors designed from computer-generated templates bind as predicted. Org Lett 3:2309-12
Dales, N A; Bohacek, R S; Satyshur, K A et al. (2001) Design and synthesis of unsymmetrical peptidyl urea inhibitors of aspartic peptidases. Org Lett 3:2313-6
Bursavich, M G; West, C W; Rich, D H (2001) From peptides to non-peptide peptidomimetics: design and synthesis of new piperidine inhibitors of aspartic peptidases. Org Lett 3:2317-20
Flentke, G R; Glinski, J; Satyshur, K et al. (1999) Purification and crystallization of rhizopuspepsin: the use of nickel chelation chromatography to select for catalytically active species. Protein Expr Purif 16:213-20
West, C W; Rich, D H (1999) Novel cyclic tripeptides and substituted aromatic amino acids via ruthenium-activated S(N)Ar reactions. Org Lett 1:1819-22

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