Dr. Graham's long term goal is to understand how the cell assembles and maintains the ordered arrangement of compartments that comprise the Golgi complex, and how this structure contributes to the function of this essential organelle.
The specific aims are: (1) to continue to define the compartmental organization of the yeast Golgi complex and the factors required for protein transport between Golgi compartments; (2) to decipher the localization signal(s) within a resident protein of the yeast Golgi complex, the Mnn1 protein (Mnn1p); (3) to isolate mutants that exhibit a defect in the Golgi localization of the Mnn1p; and (4) to isolate gene fragments that encode sorting information specific to the yeast secretory pathway.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM050409-01
Application #
2188241
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1994-01-01
Project End
1997-12-31
Budget Start
1994-01-01
Budget End
1994-12-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212