This proposal describes a program directed towards the chemical synthesis of several naturally occurring bacterial modulation signals of the legume- rhizobium factor family (e.g. 1 and 2) and a number of natural oligosaccharide ligands of selectins (e.g. 3 and 4). Furthermore this program includes molecular design, chemical synthesis and biological evaluation of analogs of the above mentioned natural compounds. Finally, the design and synthesis of novel oligosaccharide molecules, as specific compounds or combinational libraries, is proposed. The proposed research is expected to have significant implications in chemistry, biology, and medicine, particularly in the areas of nitrogen fixation, neutrition, and inflammation.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050669-04
Application #
2459522
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1994-08-01
Project End
1999-07-31
Budget Start
1997-08-01
Budget End
1999-07-31
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093