Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051469-02
Application #
2190021
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Purdue University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Talukdar, Arindam; Zhao, Yujie; Lv, Wei et al. (2012) O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase. J Org Chem 77:6239-61
Morgunova, Ekaterina; Illarionov, Boris; Saller, Sabine et al. (2010) Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis. Acta Crystallogr D Biol Crystallogr 66:1001-11
Kim, Ryu-Ryun; Illarionov, Boris; Joshi, Monika et al. (2010) Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion. J Am Chem Soc 132:2983-90
Talukdar, Arindam; Morgunova, Ekaterina; Duan, Jianxin et al. (2010) Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase. Bioorg Med Chem 18:3518-34
Zhao, Yujie; Bacher, Adelbert; Illarionov, Boris et al. (2009) Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis. J Org Chem 74:5297-303
Talukdar, Arindam; Breen, Meghan; Bacher, Adelbert et al. (2009) Discovery and development of a small molecule library with lumazine synthase inhibitory activity. J Org Chem 74:5123-34
Yu, Tsyr-Yan; O'Connor, Robert D; Sivertsen, Astrid C et al. (2008) (15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase. Biochemistry 47:13942-51
Zhang, Yanlei; Illarionov, Boris; Morgunova, Ekaterina et al. (2008) A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications. J Org Chem 73:2715-24
Zhang, Yanlei; Illarionov, Boris; Bacher, Adelbert et al. (2007) A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative. J Org Chem 72:2769-76
Kaiser, Johannes; Illarionov, Boris; Rohdich, Felix et al. (2007) A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway. Anal Biochem 365:52-61

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