Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052034-02
Application #
2190899
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Sheng, Wanyun; Liao, Xiubei (2002) Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions. Protein Sci 11:1482-91
Sheng, Wanyun; Rance, Mark; Liao, Xiubei (2002) Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence. Biochemistry 41:3286-93
Myrich, E; Shiyanova, T; Liao, X (2000) A winged helix protein from yeast Saccharomyces cerevisiae recognizes centromere sequences. Arch Biochem Biophys 375:78-82
Shiyanova, T; Liao, X (1999) The dissociation rate of a winged helix protein-DNA complex is influenced by non-DNA contact residues. Arch Biochem Biophys 362:356-62
Jin, C; Marsden, I; Chen, X et al. (1999) Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex. J Mol Biol 289:683-90
Marsden, I; Jin, C; Liao, X (1998) Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins. J Mol Biol 278:293-9
Jin, C; Marsden, I; Chen, X et al. (1998) Sequence specific collective motions in a winged helix DNA binding domain detected by 15N relaxation NMR. Biochemistry 37:6179-87
Marsden, I; Chen, Y; Jin, C et al. (1997) Evidence that the DNA binding specificity of winged helix proteins is mediated by a structural change in the amino acid sequence adjacent to the principal DNA binding helix. Biochemistry 36:13248-55
Bravieri, R; Shiyanova, T; Chen, T H et al. (1997) Different DNA contact schemes are used by two winged helix proteins to recognize a DNA binding sequence. Nucleic Acids Res 25:2888-96